Type 2 diabetes and metabolism
Group description:
Research focus
We focus on epidemiological studies, clinical observational studies, randomized clinical trials and translational research in obesity, prediabetes, gestational diabetes, metabolic syndrome and type 2 diabetes. We design and conduct our own studies, but also participate in international multi-center studies, both researcher initiated and studies sponsored by pharmaceutical companies, (phase II-IV studies).
Our aim is to contribute to prevention and improved therapy for diseases related to overweight and physical inactivity, primarily type 2 diabetes and its complications. To achieve this, we search for etiological factors in disease development through hypothesis-generating epidemiological and observational studies and seek to test the hypotheses in mechanistic and randomized, controlled clinical trials. We aim to publish our results in internationally well recognized scientific journals, and present at national and international meetings. We also engage in popular scientific publishing to increase knowledge in the public about our own and other group’s research. We collaborate closely and partly overlap with Anne Karen Jenum’s group on the STORK-Groruddalen studies, with Elisabeth Qvigstad/Tore Henriksen/Jens Bollerslev’s group on the STORK-Rikshospitalet studies and with Cecilie Wium’s group at the Lipid Clinic.
Our special focus for the coming years will be on:
genetics and epigenetics in gestational diabetes
diabetes in immigrants
molecular mechanisms for insulin resistance related to adiposity, inflammation and the effect of physical exercise and diet
large register-based epidemiological studies in type 2 diabetes
Projects
Metaflammation – transition from healthy to unhealthy obesity
The FIBERDIA – a randomized controlled trial of the effects of probiotics on glucose metabolism
The DIASA (Diabetes in South Asians) research program
The DAPHNE- , DISCOVER- and DIAFLU studies focusing on large epidemiological register studies of type 2 diabetes in Norway and a substudy of the HUNT-study focusing on anthropometric indices and cardiovascular end-points
Genetic and epigenetic sub-projects under the STORK and STORK-Groruddalen studies
The 4B study: The effect of bariatric surgery on bone marrow fat and glucose metabolism in subjects with type 2 diabetes and morbid obesity
The MyoGlu-study – molecular mechanisms for the insulin sensitizing effects of exercise
10 year follow up of subjects after bariatric surgery with focus on the prevalence of diabetes and metabolic risk factors
Group members
Kåre I. Birkeland, Professor, MD, PhD
Anne Karen Jenum, Professor, MD, PhD
Anne-Marie Aas, Associate Professor, PhD
Anh Thi Tran, MD, PhD, postdoc
Anne-Pernille Ofstad, MD, PhD
Archana Sharma, MD, PhD student
Cecilie Wium, MD, PhD, consultant, postdoc
Christine Sommer, PhD, postdoc
Christin W. Waage, PhD, postdoc
Eline Birkeland, PhD student
Elisabeth Qvigstad, MD, PhD, consultant
Gunn-Helen Moen, MSc, PhD student
Hanne Løvdal Gulseth, MD, PhD, senior researcher
Hilde Risstad, MD, PhD
Ingvild K. Blom-Høgestøl, MD, PhD student
Julia Onsrud Opsahl, Forskerlinjen, Faculty of Medicine
Kirsti Bjerkan, MSc
Line Sletner, MD, PhD, researcher
Ole Elvebakk, MD, PhD student
Paz Lopez-Doriga Ruiz, MD, PhD student
Sedegheh Gharagzlian, PhD
Sindre Lee-Ødegaard, Forskerlinjen, Faculty of Medicine
Susanna E. Hanvold, MSc, PhD
Åse Ruth Eggemoen, MD, PhD, postdoc
Åse Halsne, research nurse
Kjersti Gjems Vanberg, master student, UiO
Kristine Duus Molven, master student, UiO
Oda Kristine Smestu Holm, master student UiO
Sander Rismyr, master student UiO
Nadia Kiryushchenko, master student UiO
May-Helen Nyland Espenes, medical student project, UiO
Anne Marthe Brobakk Hansen, medical student project, UiO
Hilde Gjesdalen, medical student project, UiO