MYOGLU
- Physical activity, myokines and glucose metabolism
Skeletal muscles account for ~ 40 % of body weight and normal glucose uptake and metabolism in skeletal muscles are essential to keep blood glucose within normal range. Hence, impaired skeletal muscle glucose uptake is a major cause of the insulin resistance in type 2 diabetes, and therefore physical activity is essential for health. The term myokine is used to describe proteins secreted from skeletal muscle that can execute important biological functions locally in the muscle (paracrine) or in other organs like the brain, liver, pancreas and intestines (endocrine).
Aims of the present study
We want to quantify the effect of combined strength and endurance training on metabolic health among subjects with normal and elevated glucose levels, and explore potential myokines that can explain the effects of exercise.
Methods
We will perform an intervention concerning physical activity among subjects with overweight (BMI in the range of 27 to 32 kg/m2) and abnormal glucose metabolism, evaluated by oral glucose tolerance test (OGTT), and compare their phenotypic changes with healthy, normal weight control subjects (BMI in the range of 19 to 25 kg/m2). The intervention will include strength as well as endurance training, lasting 8 weeks and we will recruit 12 subjects in each group (with abnormal glucose metabolism and control subjects). All the test individuals will be exposed to training by personal coaches four times weekly for 8 weeks and to extensive examinations before and after the training period. Muscle strength, aerobic capacity, insulin sensitivity (glucose clamp), fat- and muscle biopsies as well as extensive serum markers will be measured before and after the intervention period.
News from 2022:
We have published a review based partly on knowledge created in this study. Further analyses of collected samples are ongoing and publications are planned.
Publications 2022:
Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance. Lee-Ødegård S, Olsen T, Norheim F, Drevon CA, Birkeland KI. Metabolites. 2022 Feb 25;12(3):208. doi: 10.3390/metabo12030208. PMID: 35323652