Pregnancy as a “stress test for life” – A Longitudinal Extension of the STORK Cohort
The STORK project is a prospective cohort study following 1031 pregnant Norwegian women from week 12-14 until the first week post-partum, included at Oslo University Hospital, Rikshospitalet. The participants (300 women) have been have been re-evaluated 5 years post-partum.
Investigating early development and mechanisms of gestational diabetes mellitus associated with later metabolic complications and cardiovascular disease may gain important information about women’s later health and increase chances to prevent further progression of these diseases.
To reach our goals we perform translational research, using our well-defined clinical cohort investigating blood samples, placenta biopsies and performing in-vitro studies exploring mechanistic functions and regulations.
News from 2024:
In a collaboration with section of endocrinology, we found an increase in adipose tissue mass both at short- and long-term follow-up in acromegaly while glucose metabolism improves rapidly after disease control and persists.
In a collaboration with the obstetrics department, we found that overweight or obese women had smaller pregnancy-related metabolic alterations than normal-weight/underweight women. There was a trend toward higher triglyceride and VLDL particle concentration in overweight/obese women.
Publications 2024:
Falch CM, Godang K, Lekva T, Ueland T, Heck A, Bollerslev J, Olarescu NC. Long-term depot specific changes in adipose tissue after treatment of acromegaly. Eur J Endocrinol. 2024;190(3):K37-K42
Skytte HN, Roland MCP, Christensen JJ, Holven KB, Lekva T, Gunnes N, Michelsen TM. Maternal metabolic profiling across body mass index groups: An exploratory longitudinal study. Acta Obstet Gynecol Scand. 2024;103(3):540-50