Metabolomic profiling of hyperglycemic clamp in humans

Nearly 90% of the gnomically inherited risk of type 2 diabetes is in genes regulating beta cell function. Understanding the relationship between these findings and the pathophysiological development of type 2 diabetes is important.  It has been reported that different metabolites are important for GSIS in humans. 

We use untargeted metabolomic and proteomic profiling in samples form humans- both with and without type 2 diabetes – to investigate the difference in metabolomic and proteomic profiling between patients and healthy controls during hyperglycemic and euglycemic clamps.

2021: This project is still running.

Primary Investigator: Per Medbøe Thorsby, MD, PhD – Hormone laboratory, OUS

Co-investigators/participants:  
Milaim Pepaj, Mcs, PhD - Senter for psykofarmakologi, Diakonhjemmet sykehus