Metabolomic profiling of hyperglycemic clamp in humans
Nearly 90% of the gnomically inherited risk of type 2 diabetes is in genes regulating beta cell function. Understanding the relationship between these findings and the pathophysiological development of type 2 diabetes is important. It has been reported that different metabolites are important for GSIS in humans.
We use untargeted metabolomic and proteomic profiling in samples form humans- both with and without type 2 diabetes – to investigate the difference in metabolomic and proteomic profiling between patients and healthy controls during hyperglycemic and euglycemic clamps.
2021: This project is still running.